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Ligandrol did not always result in fat loss in the studies, it mainly promoted muscle growth and a dose related increase in lean body mass, . In the current study we find that ligandrol does not result in a significantly higher fat loss during weight training and only after a long training period the effects appear to be reversed. This study is the only one investigating the effects of long-term (10 weeks) ligandrol supplementation compared to a low dose ligandrol supplement  with the only previous report on a study in this timeframe  . We do not have any information on the effect on body weight from long-term ligandrol supplementation before or after training. It has been recently shown  that a single daily supplement with lignans (dideoxyribonucleic acid, 5-(4-dimethylurafloroimidazoline)-1-[2-[4,5-dimethylhydrazinyl]-methylamino]-1-pyrazo-(1-hydroxyethyl)pyrimidine) can significantly increase body weight and thus body fat  . There is also no evidence on the potential benefits from long-term ligandrol supplementation alone  .It has been proposed that long-term training may increase lipolysis. After training LIPolysis is often measured for three days and during recovery the level of lipolysis may decrease, this is usually considered a negative result. However, the authors of this study found that LIPolysis measured during training has not changed from baseline but has remained stable over the 10 week training period  . To examine whether LIPolysis differs between groups LIPolysis was measured before and after training using different methods  . All groups showed a significant increase in LIPolysis at all time points of the training period indicating that Lipolysis has increased. Interestingly, the effects of exercise on LIPolysis also changed significantly from baseline to the following training period and were dependent of dose as the dose-dependent increase in LIPolysis was higher when the doses were low compared to when they were high. It has been argued that this finding might be due to the high energy expenditure of high intensity exercise  . However, this study found a similar response of both training groups, i.e. both were able to increase LIPolysis, even though the exercise intensity was not as high  .The present study is the first study to investigate the effect of long-term exercise with different intensities (6-12 RMSimilar articles: